Minor Contribution of inhA-15 Mutations to the Rapid Detection of Isoniazid Resistance in Mycobacterium Tuberculosis Isolates

نویسندگان

  • Azam Ahmadi Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, Iran
  • Hossein Sarmadian Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, Iran
  • Manijeh Kahbazi Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, Iran
  • Maryam Sadrnia Department of Biology, Payame Noor University, Iran
  • Mohammad Reza Zolfaghari Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
  • Reza Moaddab Medical Laboratory Sciences and Research Center for TB and Pulmonary Diseases, Tabriz University of Medical Sciences, Tabriz, Iran
  • Roya Abkar Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
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minor contribution of inha-15 mutations to the rapid detection of isoniazid resistance in mycobacterium tuberculosis isolates

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Screening of 127 isoniazid (INH)-resistant Mycobacterium tuberculosis isolates from Singapore for mutations within the dfrA and inhA genes revealed mutations in 0 and 5 (3.9%) isolates respectively, implying that mutations in dfrA do not contribute to the detection of INH-resistant M. tuberculosis and that mutations within inhA are rare. Thirty-seven (29%) of the 127 isolates had no mutations i...

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Isoniazid MIC and KatG Gene Mutations among Mycobacterium tuberculosis Isolates in Northwest of Iran

Objective(s) Isoniazid (INH) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. Resistance to INH is mediated mainly by mutation in KatG gene that is coded for the catalase enzyme. The proportional method for detection of INH-resistance is time consuming due to the slo...

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Multiple mutations in katG and inhA identified in Thai isoniazid-resistant Mycobacterium tuberculosis isolates.

A total of 29 Thai multi-drug-resistant/isoniazid-resistant Mycobacterium tuberculosis isolates were analyzed for mutations in katG from codons 254 to 549, inhA promoter and inhA open reading frame by DNA sequencing and single strand conformation polymorphism. Twenty-five multi-drug resistant isolates exhibited single point mutations (17 isolates at Ser315Thr plus Arg463Leu, 1 at Thr308Pro plus...

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Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China.

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عنوان ژورنال

دوره 41  شماره 2

صفحات  161- 163

تاریخ انتشار 2016-03-01

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